The first thing that might strike you about Huston is his family resemblance to a couple of other famous people: director John Huston and actress Anjelica Huston, who are his father and half-sister, respectively. John Huston is a legendary American filmmaker, responsible for classics such as The Treasure of the Sierra Madre, The African Queen, and Prizzi's Honor. Anjelica Huston, meanwhile, has appeared in dozens of movies — perhaps most iconically as Morticia Addams in the Addams Family film series. These family connections helped Danny Huston as he launched his career, with his father producing his first project as a director, 1988's Mr. North.

From there, Huston jumped into acting with a bit role as Bartender #2 in the 1995 drama Leaving Las Vegas. He then bounced around in a few other projects before landing what would be his breakthrough part in the 2000 indie Ivans Xtc. Loosely based on Leo Tolstoy's The Death of Ivan Ilyich, the film was a hit at that year's Independent Spirit Awards, netting Huston a Best Male Lead nod. The early 2000s were very good to the actor — including a supporting role in Martin Scorsese's The Aviator, the ensemble of which won a 2004 SAG Aaward, and a role as Sandy Woodrow in the critically-acclaimed thriller The Constant Gardener, for which he won a Satellite Award for Best Supporting Actor.