Never say never, right? After all, if enough fans are hungry for a Spider-Man 4, set in the Raimi-verse, that perhaps features an older Maguire and caps off all the loose ends, ala Logan, then Sony has probably considered the notion, themselves. Whether they pursue it or not, though, is a different matter entirely.
The fact that multiverse narratives are taking off, since Avengers: Endgame and Spider-Man: Into the Spider-Verse, definitely increases the possibility of this, though. Particularly since the new Doctor Strange movie, Doctor Strange in the Multiverse of Madness, will be directed by Raimi himself. If you look into the future and imagine a world where Strange opens one of his glowing portals to another dimension, only for Maguire's Spider-Man to come swinging right in ... well, the audience reaction would be explosive, to say the least.
Raimi has never directly answered questions about if it's something he's up for. However, in 2019, when Yahoo! News asked if he ever thought about Spider-Man 4, he answered, "I think about it all the time. It's hard not to, because each summer another Spider-Man film comes out! So when you have an unborn one, you can't help but think what might have been. But I try to focus on what will be, and not look into the past."
Note, that doesn't rule out Spider-Man 4 happening in the future. Amid unconfirmed rumors that Holland's third Spidey flick might open the door to a "Spider-Verse" storyline, talk of Raimi and Maguire doing one last hurrah is likely to only escalate from here on, whether it happens or not. Stay tuned.
