During a December 2021 interview with Entertainment Tonight, Pauline Chalamet was asked what she thinks of the comparisons between "The Sex Lives of College Girls" and "Sex and the City." Chalamet said she agreed with the comparison — especially in one regard. Chalamet said, "One thing where there is something really cool and similar is that we're talking about four very distinct characters. And I think that our show does a really good job of four different, distinct characters. And we can all relate to each other in different ways, but I love that."

Fans of "The Sex Lives of College Girls" definitely know that the four main characters couldn't be more different from one another. Kimberly is shy and awkward without much sexual experience (at least at the show's start), while Bela is highly outgoing, loves making jokes, and is exceptionally sex-positive. Leighton, meanwhile, sticks out from the group with her often-judgmental and uppity attitude, while Whitney is more warm and welcoming. Plus, there are the differences in their backgrounds — for example, Kimberly grew up in a small town and has to take a work-study job to pay for her college life, while Leighton grew up in New York City and comes from a super wealthy family.

"Sex and the City" also sees a lot of differences between the four central characters, such as the fact that Samantha couldn't be any more comfortable with sex. At the same time, there are many topics relating to sex that Charlotte shies away from.