Ana de la Reguera has garnered an impressive array of acting credits, including beginning her career with many Spanish language roles. Her first role, the 1996 television show "Azul," is a telenovela about the Mexico City Aquarium. From there Reguera continued to pop up in other Spanish roles like "Desencuentro," "Mujer, casos de la vida real," and "Luciana y Nicolás." However, her first major work that English-speaking audiences will recognize Reguera from is the 2006 comedy film "Nacho Libre." This movie follows hopeful luchador Ignacio (Jack Black), a cook at a Mexican monastery, who dreams of becoming successful in order to support local orphans.
Unfortunately, Ignacio is generally forbidden from engaging in professional wrestling, which forces him to obfuscate his actions throughout much of the movie. Luckily, Ignacio eventually earns the respect and love of Sister Encarnación (Reguera), and she is instrumental in providing the spark Ignacio needs to win. Sister Encarnación acts as a teacher for the same orphans that Ignacio is attempting to aid, so the two have very much in common when it comes to life goals and motivations.
In an interview with People in 2021, Reguera explained that she looked back at her time in "Nacho Libre" fondly. She added, "It was the most chill, cool, fun, organized production. But you know what I remember the most, actually? That gives me a lot of nostalgia because it's also been 15 years and that shows how much the world has changed."