With their twincestual brood no longer in the picture, things will likely change between Cersei and Jaime, especially after he realizes the lengths Cersei went to in order to permanently separate church and state. We have a feeling she'll cross the line again, perhaps to the point that Jaime feels he needs to backstab another ruler he swore to protect.
In the books, young Cersei received a prophecy predicting she'd be killed by "Valonqar." For those rusty in High Valyrian, that's the word for "Little Brother." Sure, that could mean Tyrion, but he already killed their father. Based on the Valonqar prophecy, Cersei's inevitable killer could also be Bran Stark or even the Hound, Sandor Clegane, but our money is ultimately on the Kingslayer becoming a Queenslayer: Cersei was born just before Jaime.
