As of now, neither Adam Sandler nor Sony released any specific reason as to why the actor left. Sandler was not the only one to depart from the franchise. The film also saw Kevin James get replaced by Brad Abrell as the voice of Frankenstein. Similarly, director Genndy Tartakovsky (also known for his Cartoon Network and Adult Swim shows such as "Dexter's Laboratory," "Star Wars: Clone Wars," and "Primal") announced he was stepping down from the director's chair (via Collider). The reins would be handed to newcomers Derek Drymon and Jennifer Kluska, although Tartakovsky would remain as a co-writer and executive producer.

Taking Sandler's place would be voice actor and YouTuber, Brian Hull. In discussing Hull's addition to the cast with Animation Scoop, co-director Drymon said, "He did a great job. Big shoes to fill ... He worked really hard to kind of find the voice that people are familiar with. But also because the character transforms into a human, there's an opportunity to bring something new to it." That last part seems to be the only hint as to why the role was swapped.

Before this, Hull was primarily known for his cartoon character impressions. He continues to do this on his YouTube channel, which currently has 2.3 million subscribers. Although "Transformania" would be his first feature film, it would not be the actor's first time voicing the character of Dracula. In 2021, the actor first debuted in the role with the "Transylvania" short film, "Monster Pets."