Christina Applegate was a fan favorite as lovable blonde bombshell Kelly Bundy on Married...with Children, but finding another hit series has been easier said than done in the years since the show's cancellation. Her first starring sitcom role, as the titular single mom in NBC's Jesse, lasted only two seasons between 1998-2000; her next TV project, ABC's Samantha Who?, was canceled after 35 episodes. She's continued to work in film, co-starring in hits like The Sweetest Thing and the Anchorman movies, but it hasn't improved her television luck—her third shot at post-Married sitcom hit, Up All Night, was also off the air after two seasons and 35 episodes. But all that professional turmoil is nothing compared to the personal battle she faced in 1998, when Applegate discovered she had breast cancer. Luckily, it was found in its early stages, and after a double mastectomy, she emerged cancer free.