One of Dr. Now's patients featured in the teaser promo is named Margaret Johnson, a 35-year-old woman who first appears on the show at 750 lbs. In the first moments of the promo, she is seen struggling to walk around a room, utilizing a walker to find her way to the bathroom. Like with other patients on the series, Dr. Now's goal is to help Johnson lose weight in order to prolong her life.

She is heard in the promo saying, "Every day I question whether or not I should keep going like this." Later in the promo, Johnson is seen crying as she sits in front of a desk. In response, a woman quietly asks Johnson "What's the matter?" In tears, Johnson replies simply, "I'm hurting."

Johnson is one of thirteen subjects that "My 600-Lb Life" will focus on in the 13-episode tenth season of the long-running series. The new season of "My 600-Lb Life" premieres on Wednesday, November 3.