One thing that has characterized the family's weight loss journey is their relationship with each other. Whether they're a close-knit support system or enablers of each others' weight gain has been called into question in the show, and though the Perrios have tried to prove suggestions that they might be better off apart wrong, their "Where Are They Now?" episode showed that therapy has helped them come to terms with the fact that relying on each other too much isn't always a good thing.
Life hasn't always been easy for the Perrios, but fortunately, not a single one of them has joined the ranks of "My 600-Lb Life" stars who have passed away as of 2023. Roshanda is active on Instagram, and often posts images of the family spending time together, which means that their difficult journey hasn't driven them apart. The siblings also maintain a collective, sporadically updated Facebook page that shows Clarence has continued to shed pounds over the years.