Much of the cast for "Saving Bikini Bottom: The Sandy Cheeks Movie" has already been built out. Just as with previous "SpongeBob SquarePants" movies, most of the voice cast from the original series will be reprising their respective roles for this cinematic outing. Per Netflix's information on the movie, it will feature Carolyn Lawrence as Sandy, Tom Kenny as SpongeBob, Clancy Brown as Mr. Krabs, Bill Fagerbakke as Patrick, Mr. Lawrence as Plankton, and Rodger Bumpass as Squidward.

Additionally, the movie will feature some other major names lending their voice acting talents to certain characters. That list includes Wanda Sykes ("History of the World: Part II"), Johnny Knoxville ("Jackass"), Craig Robinson ("The Office"), Grey DeLisle ("Invincible"), Ilia Isorelýs Paulino ("The Sex Lives of College Girls"), and Matty Cardarople ("Stranger Things"). It's currently unknown which characters these actors will be playing.