By the time CBS officially canceled Scorpion, the cast seemed to have made their peace with the show coming to an early end. Shortly after the news was announced, Katherine McPhee, who starred as former waitress Paige, tweeted, "thank you so much to @CBS for this journey, to my awesome cast mates and crew whom I learned from every day and to all the wonderful @ScorpionCBS fans for being so passionate about what we created. we'll always be a family. #TeamScorpion."

McPhee's co-star Robert Patrick also tweeted about the news, adding, "Thank you to all the fans! The writers, the crew, the cast, and @CBS it's been a great story to tell and a hell of a run! On to the next! #loveya #TeamScorpion @ScorpionCBS." The rest of the cast had a similar response, suggesting that they knew Scorpion's fate was sealed, despite fans' attempts to mount last-minute renewal campaigns.