You could come up with some fairly reasonable explanations for why American Pickers has never set foot in some states. However, there are others that may come as more of a shock, particularly Nevada. You would think Wolfe and Fritz would be drooling at the opportunity to journey into Nevada to try to find some vintage gambling paraphernalia related to the history of Las Vegas. Of course, Nevada has a drier climate than most other states, which doesn't preserve items as well as states with a fair amount of humidity. Still, you would think there would be something out there to attract the pickers' attention. 

The same holds true for Nevada's neighbor, Utah, as well as Delaware. The latter is about as far east as you can get, so it's possible the guys just haven't driven that far yet. But when it comes to Utah, surely they must have driven through there to reach some of their other destinations. Was there really nothing there for them to find? 

All in all, there's no stated reason why American Pickers has never filmed in these states. There's a very good possibility it's completely unintentional, and it just hasn't happened yet. Also, if the show gets picked up for season 22, then there is always a chance Wolfe and Fritz will soon be haggling over prices in Montana, after all.