As a U.S. Army veteran, Alicia West finds herself at a bit of a crossroads when she returns home to New Orleans. After joining the police force there, she's reminded by her partner, Kevin Jennings (Reid Scott) that there's an inherent distrust between their department and the predominantly Black community they will be policing. Alicia quickly understands why, after she witnesses Detective Terry Malone (Frank Grillo) murder an unarmed suspect, and then tries to cover his crime up.
After Malone realizes that Alicia's body camera captured evidence of the murder, he and his men make it clear they'd rather kill her or frame her for the murder than be held accountable for their actions. Alicia is forced to flee, and ends up taking refuge with business owner Milo Jennings (Tyrese Gibson), who reluctantly agrees to help her.
Alicia is then at a crossroads of another kind, and as she navigates an increasingly dangerous fight for her life, the bulk of Black and Blue sees Alicia grappling with two separate, but equally important objectives: getting her body cam footage to safety, and staying alive so she can clear her name and bring Malone to justice.
Luckily, she succeeds at both tasks. Milo sneaks into the police department and uploads the footage. Malone catches up to Alicia, and the two engage in a tense parking lot standoff, with many members of the community looking on. After a dispatcher who witnesses the footage at the police department announces to the officers that Alicia is innocent, Malone attempts to kill her one last time, before Jennings shoots him in the chest.
