Noé Archiviste hopes to find the legendary Book of Vanitas, a relic with extraordinary powers. Aboard a 19th century blimp, he meets Vanitas, the newest inheritor of the ancient text. Together, they search for sick vampires and use the power of the book to heal them. 

Most animes' first seasons usually follow up to the manga's sixth or seventh volume, so we can expect this series to do the same. Within those approximately 40 chapters, the adaptation will depict Noé's first meeting with Vanitas, how Vanitas utilizes the book to get the job done, the introductions of Luca, Jeanne, and Dominique, Noé's relationship with the mysterious Teacher, and the risks of dealing with bloodsuckers and the Charlatan that threatens to undo Vanitas' work and continue to corrupt any vampires. 

Though there are more than seven volumes currently published, fans will have to wait for the "Case Study of Vanitas" to get renewed if they want to see the next adventure animated.