Ellen Pompeo guest starred in "Law & Order" Season 6 Episode 16 ("Savior") — only six years after the show's premiere in 1990 — and "Law & Order" Season 10 Episode 15 ("Fools for Love"). In both episodes, she portrays characters police suspect knows more than they're telling. Her appearance in the former episode, aired in 1996, actually stood as one of her first gigs as a young actress. Pompeo played Jenna Weber, a young woman whose father is accused of killing her brother and mother.

It was an impressive debut for Pompeo, where she even got to be questioned by Jack McCoy (Sam Waterston), a cornerstone character to the Dick Wolf-produced drama, in a tense and classic "Law & Order" courtroom scene. In her second appearance in 2000, Pompeo portrayed Laura Kendrick, the partner of a killer, Peter Williams (Samuel Ball), who murders her sister and one of her friends. Kendrick is suspected of luring the victims, and she ends up getting 25 to life. Williams, meanwhile, receives a death sentence. Both appearances by Pompeo are impressive, but it's the second, where as a more seasoned performer, she really dug her teeth into the deceptive nature of her character.