Mills, the spaceman played by Adam Driver in "65," goes on the dangerous mission that accidentally brings him to prehistoric Earth in the first place because his daughter (Chloe Coleman) is dying of some unnamed space illness. We eventually learn that his daughter has died while he was on the mission, making him the perfect candidate for having a new surrogate daughter, Koa (Arianna Greenblatt), the only other survivor of the spaceship crash.
There's nothing untoward about this heartfelt storyline, but it could get a little emotionally intense to watch with your kids, so maybe it's worth a heads-up about. As for the more traditional thematic content found in the film, it's full of some surprisingly intense (although solidly PG-13) gore in its sci-fi-meets-dinosaurs action, and if your kids are sensitive about violence against dinosaurs, you might want to save this one for later.
In one scene, Driver is shown pulling a piece of metal shrapnel out of his own flesh, another graphic moment that younger kids might want to have their eyes shielded from. And if you're concerned about profanity, there are a few mild obscenities in the film, but nothing too beyond the pale for someone being chased around on a strange planet by dinosaurs.
All in all, most parents would probably consider "65" suitable for kids interested in science fiction adventure and/or dinosaurs, which probably includes most human children.